#include <BloodChemistry.h>

Inheritance diagram for biogears::BloodChemistry:

[legend]

Public Member Functions
virtual	~BloodChemistry () override

const char *	classname () const override

size_t	hash_code () const override

void	Clear () override
	Deletes all members. More...

void	Initialize () override
	Initializes system properties. More...

bool	Load (const CDM::BioGearsBloodChemistrySystemData &in)

CDM::BioGearsBloodChemistrySystemData *	Unload () const override
	Deletes all members. More...

void	AtSteadyState () override
	Notify systems that steady state has been achieved. More...

void	PreProcess () override
	Blood Chemistry Preprocess method. More...

void	Process () override
	Blood Chemistry process method. More...

void	PostProcess () override
	Blood Chemistry postprocess method. More...

bool	CalculateCompleteBloodCount (SECompleteBloodCount &cbc)
	Sets data on the complete blood count object. More...

bool	CalculateComprehensiveMetabolicPanel (SEComprehensiveMetabolicPanel &cmp)
	Sets data on the metabolic panel object. More...

SEScalar &	CalculateCoagulationSOFA ()

void	CalculateHemolyticTransfusionReaction (bool rhMismatch=false)
	Reaction when incompatible blood is transfused. More...

Public Member Functions inherited from biogears::SEBloodChemistrySystem
	SEBloodChemistrySystem (Logger *logger)

	~SEBloodChemistrySystem () override

const SEScalar *	GetScalar (const char *name) override

const SEScalar *	GetScalar (const std::string &name) override
	A reflextion type call that will return the Scalar associated with the string. ex. GetScalar("Hematocrit") will return the SEScalarPercent object associated with Hematocrit More...

bool	HasTotalBilirubin () const

SEScalarMassPerVolume &	GetTotalBilirubin ()

double	GetTotalBilirubin (const MassPerVolumeUnit &unit) const

virtual bool	HasInflammatoryResponse () const

virtual SEInflammatoryResponse &	GetInflammatoryResponse ()

virtual SEInflammatoryResponse &	GetInflammatoryResponse () const

bool	Load (const CDM::BloodChemistrySystemData &in)
	Clears this object then creates and sets members to data in the bind object More...

Tree< const char * >	GetPhysiologyRequestGraph () const override
	Clears this object then creates and sets members to data in the bind object More...

bool	HasBloodDensity () const
	Check to see if an property or child object has been allocated. More...

SEScalarMassPerVolume &	GetBloodDensity ()
	Return the Property/Child object, if it does not exist, it will be allocated. More...

double	GetBloodDensity (const MassPerVolumeUnit &unit) const
	Returns the value of the Property, NaN is returned if the property does not exist. More...

bool	HasArterialBloodPH () const
	Test if member has been allocated More...

SEScalar &	GetArterialBloodPH ()
	Get member class, allocate if nullptr. More...

double	GetArterialBloodPH () const
	Test if member has been allocated More...

bool	HasArterialBloodPHBaseline () const
	Test if member has been allocated More...

SEScalar &	GetArterialBloodPHBaseline ()
	Get member class, allocate if nullptr. More...

double	GetArterialBloodPHBaseline () const
	Test if member has been allocated More...

bool	HasVenousBloodPH () const
	Test if member has been allocated More...

SEScalar &	GetVenousBloodPH ()
	Get member class, allocate if nullptr. More...

double	GetVenousBloodPH () const
	Test if member has been allocated More...

bool	HasBloodSpecificHeat () const
	Test if member has been allocated More...

SEScalarHeatCapacitancePerMass &	GetBloodSpecificHeat ()
	Get member class, allocate if nullptr. More...

double	GetBloodSpecificHeat (const HeatCapacitancePerMassUnit &unit) const
	Test if member has been allocated More...

bool	HasBloodUreaNitrogenConcentration () const
	Test if member has been allocated More...

SEScalarMassPerVolume &	GetBloodUreaNitrogenConcentration ()
	Get member class, allocate if nullptr. More...

double	GetBloodUreaNitrogenConcentration (const MassPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasCarbonDioxideSaturation () const
	Test if member has been allocated More...

SEScalarFraction &	GetCarbonDioxideSaturation ()
	Get member class, allocate if nullptr. More...

double	GetCarbonDioxideSaturation () const
	Test if member has been allocated More...

bool	HasCarbonMonoxideSaturation () const
	Test if member has been allocated More...

SEScalarFraction &	GetCarbonMonoxideSaturation ()
	Get member class, allocate if nullptr. More...

double	GetCarbonMonoxideSaturation () const
	Test if member has been allocated More...

bool	HasHematocrit () const
	Test if member has been allocated More...

SEScalarFraction &	GetHematocrit ()
	Get member class, allocate if nullptr. More...

double	GetHematocrit () const
	Test if member has been allocated More...

bool	HasHemoglobinContent () const
	Test if member has been allocated More...

SEScalarMass &	GetHemoglobinContent ()
	Get member class, allocate if nullptr. More...

double	GetHemoglobinContent (const MassUnit &unit) const
	Test if member has been allocated More...

bool	HasHemoglobinLostToUrine () const
	Test if member has been allocated More...

SEScalarMass &	GetHemoglobinLostToUrine ()
	Get member class, allocate if nullptr. More...

double	GetHemoglobinLostToUrine (const MassUnit &unit) const
	Test if member has been allocated More...

bool	HasOxygenSaturation () const
	Test if member has been allocated More...

SEScalarFraction &	GetOxygenSaturation ()
	Get member class, allocate if nullptr. More...

double	GetOxygenSaturation () const
	Test if member has been allocated More...

bool	HasOxygenVenousSaturation () const
	Test if member has been allocated More...

SEScalarFraction &	GetOxygenVenousSaturation ()
	Get member class, allocate if nullptr. More...

double	GetOxygenVenousSaturation () const
	Test if member has been allocated More...

bool	HasPhosphate () const
	Test if member has been allocated More...

SEScalarAmountPerVolume &	GetPhosphate ()
	Get member class, allocate if nullptr. More...

double	GetPhosphate (const AmountPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasPlasmaVolume () const
	Test if member has been allocated More...

SEScalarVolume &	GetPlasmaVolume ()
	Get member class, allocate if nullptr. More...

double	GetPlasmaVolume (const VolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasPulseOximetry () const
	Test if member has been allocated More...

SEScalarFraction &	GetPulseOximetry ()
	Get member class, allocate if nullptr. More...

double	GetPulseOximetry () const
	Test if member has been allocated More...

bool	HasRedBloodCellAcetylcholinesterase () const
	Test if member has been allocated More...

SEScalarAmountPerVolume &	GetRedBloodCellAcetylcholinesterase ()
	Get member class, allocate if nullptr. More...

double	GetRedBloodCellAcetylcholinesterase (const AmountPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasRedBloodCellCount () const
	Test if member has been allocated More...

SEScalarAmountPerVolume &	GetRedBloodCellCount ()
	Get member class, allocate if nullptr. More...

double	GetRedBloodCellCount (const AmountPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasStrongIonDifference () const
	Test if member has been allocated More...

SEScalarAmountPerVolume &	GetStrongIonDifference ()
	Get member class, allocate if nullptr. More...

double	GetStrongIonDifference (const AmountPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasShuntFraction () const
	Test if member has been allocated More...

SEScalarFraction &	GetShuntFraction ()
	Get member class, allocate if nullptr. More...

double	GetShuntFraction () const
	Test if member has been allocated More...

bool	HasTotalProteinConcentration () const
	Test if member has been allocated More...

SEScalarMassPerVolume &	GetTotalProteinConcentration ()
	Get member class, allocate if nullptr. More...

double	GetTotalProteinConcentration (const MassPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasRhTransfusionReactionVolume () const
	Test if member has been allocated More...

virtual SEScalarVolume &	GetRhTransfusionReactionVolume ()
	Test if rh mismatch More...

double	GetRhTransfusionReactionVolume (const VolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasVolumeFractionNeutralPhospholipidInPlasma () const
	Test if member has been allocated More...

SEScalarFraction &	GetVolumeFractionNeutralPhospholipidInPlasma ()
	Get member class, allocate if nullptr. More...

double	GetVolumeFractionNeutralPhospholipidInPlasma () const
	Test if member has been allocated More...

bool	HasVolumeFractionNeutralLipidInPlasma () const
	Test if member has been allocated More...

SEScalarFraction &	GetVolumeFractionNeutralLipidInPlasma ()
	Get member class, allocate if nullptr. More...

double	GetVolumeFractionNeutralLipidInPlasma () const
	Test if member has been allocated More...

bool	HasWhiteBloodCellCount () const
	Test if member has been allocated More...

SEScalarAmountPerVolume &	GetWhiteBloodCellCount ()
	Get member class, allocate if nullptr. More...

double	GetWhiteBloodCellCount (const AmountPerVolumeUnit &unit) const
	Test if member has been allocated More...

bool	HasArterialCarbonDioxidePressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetArterialCarbonDioxidePressure ()
	Get member class, allocate if nullptr. More...

double	GetArterialCarbonDioxidePressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasArterialOxygenPressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetArterialOxygenPressure ()
	Get member class, allocate if nullptr. More...

double	GetArterialOxygenPressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasPulmonaryArterialCarbonDioxidePressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetPulmonaryArterialCarbonDioxidePressure ()
	Get member class, allocate if nullptr. More...

double	GetPulmonaryArterialCarbonDioxidePressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasPulmonaryArterialOxygenPressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetPulmonaryArterialOxygenPressure ()
	Get member class, allocate if nullptr. More...

double	GetPulmonaryArterialOxygenPressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasPulmonaryVenousCarbonDioxidePressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetPulmonaryVenousCarbonDioxidePressure ()
	Get member class, allocate if nullptr. More...

double	GetPulmonaryVenousCarbonDioxidePressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasPulmonaryVenousOxygenPressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetPulmonaryVenousOxygenPressure ()
	Get member class, allocate if nullptr. More...

double	GetPulmonaryVenousOxygenPressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasVenousCarbonDioxidePressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetVenousCarbonDioxidePressure ()
	Get member class, allocate if nullptr. More...

double	GetVenousCarbonDioxidePressure (const PressureUnit &unit) const
	Test if member has been allocated More...

bool	HasVenousOxygenPressure () const
	Test if member has been allocated More...

SEScalarPressure &	GetVenousOxygenPressure ()
	Get member class, allocate if nullptr. More...

double	GetVenousOxygenPressure (const PressureUnit &unit) const
	Test if member has been allocated More...

Public Member Functions inherited from biogears::SESystem
	SESystem (Logger *logger)

virtual	~SESystem ()

bool	Load (const CDM::SystemData &in)

Public Member Functions inherited from biogears::Loggable
	Loggable ()

	Loggable (Logger *log)

virtual	~Loggable ()

virtual Logger *	GetLogger () const

Static Public Member Functions
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()
	Hopefully this returns a unique ID for every type. More...

Static Public Member Functions inherited from biogears::SEBloodChemistrySystem
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()

Static Public Member Functions inherited from biogears::SESystem
static const SEScalar *	GetScalar (const char name, std::vector< SESystem > *systems)

static const SEScalar *	GetScalar (const std::string &name, std::vector< SESystem * > *systems)

Protected Member Functions
	BloodChemistry (BioGears &bg)

void	Unload (CDM::BioGearsBloodChemistrySystemData &data) const

void	SetUp () override
	Initializes parameters for BloodChemistry Class. More...

void	CheckBloodSubstanceLevels ()
	Checks the blood substance (oxygen, carbon dioxide, glucose, etc.) levels and sets events. More...

void	InflammatoryResponse ()
	Track inflammation from infections, burns, and hemorrhages. More...

void	ManageSIRS ()
	Simulate effects of systemic pathogen after infection. More...

void	ProcessOverride ()
	determine override requirements from user defined inputs More...

void	OverrideControlLoop ()

Protected Member Functions inherited from biogears::SEBloodChemistrySystem
void	Unload (CDM::BloodChemistrySystemData &data) const
	Create and push all data values to a bind class More...

Protected Member Functions inherited from biogears::SESystem
void	Unload (CDM::SystemData &data) const

Protected Member Functions inherited from biogears::Loggable
virtual void	Debug (const char msg, const char origin="") const

virtual void	Debug (const std::string &msg, const std::string &origin=empty) const

virtual void	Debug (std::ostream &msg, const std::string &origin=empty) const

virtual void	Info (const char msg, const char origin="") const

virtual void	Info (const std::string &msg, const std::string &origin=empty) const

virtual void	Info (std::ostream &msg, const std::string &origin=empty) const

virtual void	Warning (const char msg, const char origin="") const

virtual void	Warning (const std::string &msg, const std::string &origin=empty) const

virtual void	Warning (std::ostream &msg, const std::string &origin=empty) const

virtual void	Error (const char msg, const char origin="") const

virtual void	Error (const std::string msg, const std::string origin=empty) const

virtual void	Error (std::ostream &msg, const std::string &origin=empty) const

virtual void	Fatal (const char msg, const char origin="") const

virtual void	Fatal (const std::string &msg, const std::string &origin=empty) const

virtual void	Fatal (std::ostream &msg, const std::string &origin=empty) const

Protected Member Functions inherited from biogears::BioGearsSystem
virtual void	LoadState ()

Static Protected Member Functions
static auto	make_unique (BioGears &bg) -> std::unique_ptr< BloodChemistry >

Protected Attributes
BioGears &	m_data

RunningAverage	m_ArterialOxygen_mmHg

RunningAverage	m_ArterialCarbonDioxide_mmHg

SEPatient *	m_Patient

SEPatientActionCollection *	m_PatientActions

double	m_redBloodCellVolume_mL

double	m_HbLostToUrine_g

double	m_RhTransfusionReactionVolume_mL

double	m_HbPerRedBloodCell_ug_Per_ct

SEInflammatoryResponse *	m_InflammatoryResponse

double	m_RhFactorMismatch_ct

SELiquidCompartment *	m_aorta

SELiquidSubstanceQuantity *	m_aortaO2

SELiquidSubstanceQuantity *	m_aortaCO2

SELiquidSubstanceQuantity *	m_aortaCO

SELiquidSubstanceQuantity *	m_aortaBicarbonate

SELiquidSubstanceQuantity *	m_brainO2

SELiquidSubstanceQuantity *	m_myocardiumO2

SELiquidSubstanceQuantity *	m_pulmonaryArteriesO2

SELiquidSubstanceQuantity *	m_pulmonaryArteriesCO2

SELiquidSubstanceQuantity *	m_pulmonaryVeinsO2

SELiquidSubstanceQuantity *	m_pulmonaryVeinsCO2

SELiquidCompartment *	m_venaCava

SELiquidSubstanceQuantity *	m_venaCavaO2

SELiquidSubstanceQuantity *	m_venaCavaCO2

SELiquidSubstanceQuantity *	m_venaCavaAlbumin

SELiquidSubstanceQuantity *	m_venaCavaAminoAcids

SELiquidSubstanceQuantity *	m_venaCavaBicarbonate

SELiquidSubstanceQuantity *	m_venaCavaCalcium

SELiquidSubstanceQuantity *	m_venaCavaChloride

SELiquidSubstanceQuantity *	m_venaCavaCreatinine

SELiquidSubstanceQuantity *	m_venaCavaEpinephrine

SELiquidSubstanceQuantity *	m_venaCavaGlucagon

SELiquidSubstanceQuantity *	m_venaCavaGlucose

SELiquidSubstanceQuantity *	m_venaCavaInsulin

SELiquidSubstanceQuantity *	m_venaCavaKetones

SELiquidSubstanceQuantity *	m_venaCavaLactate

SELiquidSubstanceQuantity *	m_venaCavaPotassium

SELiquidSubstanceQuantity *	m_venaCavaRBC

SELiquidSubstanceQuantity *	m_venaCavaSodium

SELiquidSubstanceQuantity *	m_venaCavaTriacylglycerol

SELiquidSubstanceQuantity *	m_venaCavaUrea

double	m_donorRBC_ct

double	m_patientRBC_ct

double	m_2Agglutinate_ct

double	m_p3Agglutinate_ct

double	m_d3Agglutinate_ct

double	m_4Agglutinate_ct

double	m_RemovedRBC_ct

Protected Attributes inherited from biogears::SEBloodChemistrySystem
SEScalarMassPerVolume *	m_BloodDensity

SEScalar *	m_ArterialBloodPH

SEScalar *	m_ArterialBloodPHBaseline

SEScalar *	m_VenousBloodPH

SEScalarHeatCapacitancePerMass *	m_BloodSpecificHeat

SEScalarMassPerVolume *	m_BloodUreaNitrogenConcentration

SEScalarFraction *	m_CarbonDioxideSaturation

SEScalarFraction *	m_CarbonMonoxideSaturation

SEScalarFraction *	m_Hematocrit

SEScalarMass *	m_HemoglobinContent

SEScalarMass *	m_HemoglobinLostToUrine

SEScalarFraction *	m_OxygenSaturation

SEScalarFraction *	m_OxygenVenousSaturation

SEScalarAmountPerVolume *	m_Phosphate

SEScalarVolume *	m_PlasmaVolume

SEScalarFraction *	m_PulseOximetry

SEScalarAmountPerVolume *	m_RedBloodCellAcetylcholinesterase

SEScalarAmountPerVolume *	m_RedBloodCellCount

SEScalarFraction *	m_ShuntFraction

SEScalarAmountPerVolume *	m_StrongIonDifference

SEScalarMassPerVolume *	m_TotalBilirubin

SEScalarMassPerVolume *	m_TotalProteinConcentration

SEScalarVolume *	m_RhTransfusionReactionVolume

SEScalarFraction *	m_VolumeFractionNeutralPhospholipidInPlasma

SEScalarFraction *	m_VolumeFractionNeutralLipidInPlasma

SEScalarAmountPerVolume *	m_WhiteBloodCellCount

SEScalarPressure *	m_ArterialCarbonDioxidePressure

SEScalarPressure *	m_ArterialOxygenPressure

SEScalarPressure *	m_PulmonaryArterialCarbonDioxidePressure

SEScalarPressure *	m_PulmonaryArterialOxygenPressure

SEScalarPressure *	m_PulmonaryVenousCarbonDioxidePressure

SEScalarPressure *	m_PulmonaryVenousOxygenPressure

SEScalarPressure *	m_VenousCarbonDioxidePressure

SEScalarPressure *	m_VenousOxygenPressure

SEInflammatoryResponse *	m_InflammatoryResponse

Protected Attributes inherited from biogears::SESystem
std::stringstream	m_ss

Protected Attributes inherited from biogears::Loggable
Logger *	m_Logger

Private Attributes
friend	BioGears

Friends
class	BioGearsEngineTest

Additional Inherited Members
Static Public Attributes inherited from biogears::Loggable
static const std::string	empty

static const char *	empty_cStr

Detailed Description

The Blood Chemistry System holds the system-level blood substance data that is computed on the compartment level by other systems.

The goal of the blood chemistry system in the BioGears engine is complete analysis on the blood at any given point during the simulation. The blood chemistry system houses all of the blood concentrations and compositions needed to assess a patient's health. This system is under development and will be improved in future releases to include more substances that can provide clinician level details and assessments, such as a CBC and blood panel.

Constructor & Destructor Documentation

biogears::BloodChemistry::BloodChemistry ( BioGears & bg )

protected

biogears::BloodChemistry::~BloodChemistry ( )

overridevirtual

Member Function Documentation

void biogears::BloodChemistry::AtSteadyState ( )

overridevirtual

Notify systems that steady state has been achieved.

Reimplemented from biogears::BioGearsSystem.

SEScalar & biogears::BloodChemistry::CalculateCoagulationSOFA ( )

bool biogears::BloodChemistry::CalculateCompleteBloodCount ( SECompleteBloodCount & cbc )

Sets data on the complete blood count object.

Sets data on the complete blood count object to create the CBC.

bool biogears::BloodChemistry::CalculateComprehensiveMetabolicPanel ( SEComprehensiveMetabolicPanel & cmp )

Sets data on the metabolic panel object.

Sets data on the metabolic panel object to create the metabolic panel. Uses information from the chem 14 substances that are in BioGears (see bloodchemistry-assessments)

void biogears::BloodChemistry::CalculateHemolyticTransfusionReaction ( bool rhMismatch = false )

Reaction when incompatible blood is transfused.

Blood reaction causes rbc to become agglutinated/dead and they can no longer bind gases and Hb to transport, thus causing an immune response

Todo:: Move cellular birth/death/healing to its own unique function for more accurate/responsive re-stabilizing after an event (useful outside of HTR)

void biogears::BloodChemistry::CheckBloodSubstanceLevels ( )

protected

Checks the blood substance (oxygen, carbon dioxide, glucose, etc.) levels and sets events.

Checks the oxygen, carbon dioxide, glucose, ketones, and lactate levels in specific compartments of the body. Set events for Hypercapnia, Hypoxia, Brain and MyoCardium Oxygen Deficit, Hypo/hyperglycemia and related events, ketoacidosis, and lactic acidosis based on the levels.

Event:: Patient: Hypercapnia. The carbon dioxide partial pressure has risen above 60 mmHg. The patient is now hypercapnic.

Irreversible:: The carbon dioxide partial pressure is greater than 80 mmHg.

Event:: Patient: End Hypercapnia. The carbon dioxide partial pressure has fallen below 57 mmHg. The patient is no longer considered to be hypercapnic. This event is triggered if the patient was hypercapnic and is now considered to be recovered.

Event:: Patient: Hypoxia Event. The oxygen partial pressure has fallen below 65 mmHg, indicating that the patient is hypoxic.

Irreversible:: Arterial oxygen partial pressure has been critically reduced to below 15 mmHg.

Event:: Patient: End Hypoxia Event. The oxygen partial pressure has rise above 68 mmHg. If this occurs when the patient is hypoxic, it will reverse the hypoxic event. The patient is no longer considered to be hypoxic.

Event:: Patient: Brain Oxygen Deficit Event. The oxygen partial pressure in the brain has dropped to a dangerously low level.

Irreversible:: Brain oxygen pressure has been dangerously low for more than 30 minutes.

Event:: Patient: Critical Brain Oxygen Deficit Event. The oxygen partial pressure in the brain has dropped to a critically low level.

Event:: Patient: End Brain Oxygen Deficit Event. The oxygen partial pressure has risen above 12 mmHg in the brain. If this occurs when the patient has a critical brain oxygen deficit event, it will reverse the event. The brain is not in a critical oxygen deficit.

Irreversible:: Brain oxygen pressure has been critically low for more than 10 minutes.

Event:: Patient: End Brain Oxygen Deficit Event. The oxygen partial pressure has risen above 25 mmHg in the brain. If this occurs when the patient has a brain oxygen deficit event, it will reverse the event. The brain is getting oxygen.

Event:: Patient: The heart is not receiving enough oxygen. Coronary arteries should dilate to increase blood flow to the heart.

Irreversible:: Heart has not been receiving enough oxygen for more than 40 min.

Event:: Patient: End Myocardium Oxygen Event. The heart is now receiving enough oxygen. If this occurs when the patient has a heart oxygen deficit event, it will reverse the event. The brain is getting oxygen.

const char* biogears::BloodChemistry::classname ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEBloodChemistrySystem.

void biogears::BloodChemistry::Clear ( )

overridevirtual

Deletes all members.

Reimplemented from biogears::SEBloodChemistrySystem.

size_t biogears::BloodChemistry::hash_code ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEBloodChemistrySystem.

void biogears::BloodChemistry::InflammatoryResponse ( )

protected

Track inflammation from infections, burns, and hemorrhages.

This function uses the Diverse Shock States model of Chow, 2005 to project the inflammatory response induced by various insults. The most important output from this model is Tissue Integrity, which is used to scale resistances on tissue pathways, causing the fluid shift that occurs during sepsis and in the case of large burns. The original model was calibrated for mice and considered endotoxin (pathogen by-products) to be force for infectious inflammation. Endotoxin was replaced by an actively growing pathogen population subjected to phagocytosis from local immune response, neutrophils, and macrophages. Some parameters are adjusted depending on the source of inflamamtion to better capture the time scale and magnitude of response.

\ ToDo: Investigate whether these parameters can be further optimized for humans

void biogears::BloodChemistry::Initialize ( )

overridevirtual

Initializes system properties.

Reimplemented from biogears::BioGearsSystem.

bool biogears::BloodChemistry::Load ( const CDM::BioGearsBloodChemistrySystemData & in )

auto biogears::BloodChemistry::make_unique ( BioGears & bg ) -> std::unique_ptr<BloodChemistry>

staticprotected

void biogears::BloodChemistry::ManageSIRS ( )

protected

Simulate effects of systemic pathogen after infection.

Helper function for Inflammatory Response. If the source of inflammation is a pathogen, this function is called to simulate effects of systemic pathogen infiltration that are not currently modeled mechanistically. At low infection levels, these inflammation markers will remain near their baseline values

void biogears::BloodChemistry::OverrideControlLoop ( )

protected

void biogears::BloodChemistry::PostProcess ( )

overridevirtual

Blood Chemistry postprocess method.

The current BioGears implementation has no specific postprocess functionality.

Implements biogears::BioGearsSystem.

void biogears::BloodChemistry::PreProcess ( )

overridevirtual

Blood Chemistry Preprocess method.

The current BioGears implementation only checks for active Sepsis event.

Implements biogears::BioGearsSystem.

void biogears::BloodChemistry::Process ( )

overridevirtual

Blood Chemistry process method.

The system data (blood concentrations, blood gases, and other blood properties) that are calculated or changed by other systems are set on the blood chemistry system data objects. Events are triggered at specific blood concentrations of certain substances in CheckBloodGasLevels().

Implements biogears::BioGearsSystem.

void biogears::BloodChemistry::ProcessOverride ( )

protected

determine override requirements from user defined inputs

User specified override outputs that are specific to the cardiovascular system are implemented here. If overrides aren't present for this system then this function will not be called during preprocess.

void biogears::BloodChemistry::SetUp ( )

overrideprotectedvirtual

Initializes parameters for BloodChemistry Class.

Initializes member variables and system level values on the common data model.

Implements biogears::BioGearsSystem.

static size_t biogears::BloodChemistry::TypeHash ( )

inlinestatic

static constexpr char const* const biogears::BloodChemistry::TypeTag ( )

inlinestatic

Hopefully this returns a unique ID for every type.

CDM::BioGearsBloodChemistrySystemData * biogears::BloodChemistry::Unload ( ) const

overridevirtual

Deletes all members.

Caller is now the responsible for managing returned object
I suggest you wrap the object ptr returned with a unique_ptr*

Reimplemented from biogears::SEBloodChemistrySystem.

void biogears::BloodChemistry::Unload ( CDM::BioGearsBloodChemistrySystemData & data ) const

protected

Friends And Related Function Documentation

friend class BioGearsEngineTest

friend

Member Data Documentation

friend biogears::BloodChemistry::BioGears

private

double biogears::BloodChemistry::m_2Agglutinate_ct

protected

double biogears::BloodChemistry::m_4Agglutinate_ct

protected

SELiquidCompartment* biogears::BloodChemistry::m_aorta

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_aortaBicarbonate

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_aortaCO

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_aortaCO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_aortaO2

protected

RunningAverage biogears::BloodChemistry::m_ArterialCarbonDioxide_mmHg

protected

RunningAverage biogears::BloodChemistry::m_ArterialOxygen_mmHg

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_brainO2

protected

double biogears::BloodChemistry::m_d3Agglutinate_ct

protected

BioGears& biogears::BloodChemistry::m_data

protected

double biogears::BloodChemistry::m_donorRBC_ct

protected

double biogears::BloodChemistry::m_HbLostToUrine_g

protected

double biogears::BloodChemistry::m_HbPerRedBloodCell_ug_Per_ct

protected

SEInflammatoryResponse* biogears::BloodChemistry::m_InflammatoryResponse

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_myocardiumO2

protected

double biogears::BloodChemistry::m_p3Agglutinate_ct

protected

SEPatient* biogears::BloodChemistry::m_Patient

protected

SEPatientActionCollection* biogears::BloodChemistry::m_PatientActions

protected

double biogears::BloodChemistry::m_patientRBC_ct

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_pulmonaryArteriesCO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_pulmonaryArteriesO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_pulmonaryVeinsCO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_pulmonaryVeinsO2

protected

double biogears::BloodChemistry::m_redBloodCellVolume_mL

protected

double biogears::BloodChemistry::m_RemovedRBC_ct

protected

double biogears::BloodChemistry::m_RhFactorMismatch_ct

protected

double biogears::BloodChemistry::m_RhTransfusionReactionVolume_mL

protected

SELiquidCompartment* biogears::BloodChemistry::m_venaCava

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaAlbumin

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaAminoAcids

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaBicarbonate

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaCalcium

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaChloride

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaCO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaCreatinine

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaEpinephrine

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaGlucagon

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaGlucose

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaInsulin

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaKetones

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaLactate

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaO2

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaPotassium

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaRBC

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaSodium

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaTriacylglycerol

protected

SELiquidSubstanceQuantity* biogears::BloodChemistry::m_venaCavaUrea

protected

Public Member Functions

Static Public Member Functions

Protected Member Functions

Static Protected Member Functions

Protected Attributes

Private Attributes

Friends

Additional Inherited Members

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Friends And Related Function Documentation

Member Data Documentation