Patient Methodology
Overview
Abstract
BioGears allows for patient variability via a set of parameters used to define aspects of the simulated human. These parameters are used throughout the system models to manipulate the physiological responses and homeostatic state. BioGears is deployed with several defined patients created for various testing and analysis purposes.
Introduction
The BioGears program consists of the development and integration of multiscale models for an individualized whole-body predictive patient physiology model. BioGears incorporates existing and novel models of organs and physiological systems into a whole-body model of a single generic individual within a reference population. Therefore, specific patient definitions are needed to create a virtual representation of that patient. The patient definition leverages the Commmon Data Model (CDM) to allow physiological parameters to be disseminated throughout the engine.
System Design
Background and Scope
Requirements
The BioGears patient needs to contain all user-definable parameters specific to an individual. Any parameters that are not explicitly set need to be calculated based on standard, healthy values.
Approach
Each patient parameter falls into one of three categories:
- Required: The only parameter that is required to be set on the patient at runtime is Sex. All other values not explicitly set will be determined using default values and/or calculated outputs.
- Optional: These parameters can be optionally explicitly set by the user. Many optional values have bounds associated with them to ensure a healthy initial patient.
- Unallowed: These parameters are calculated or determined through simulation based on other settings. They can not be modified by the user.
Table 1 provides the values and equations used to determine optional values not explicitly set by the user and those unallowed to be externally modified.
Features and Capabilities
Definitions
| Parameter | Modification Category | Initial Value (If not Explicitly Set) | Lower Bound | Upper Bound | Notes |
|---|---|---|---|---|---|
| Sex | Required | \[M = Male,F = Female\] | - | - | This is the only parameter required to be explicitly set. |
| Age | Optional | \[A[yr] = 44\] | 18 yr | 65 yr | No pediatric or geriatric modeling. |
| Weight | Optional | \[W[kg] = 21.75H{[m]^2}\] | Bmi = 16 kg/m2 | Bmi = 30 kg/m2 | Bmi = Body Mass Index = W[kg]/H[m]2. 21.75 kg/m2 is standard. No severly Underweight or Obese. [249] |
| Height | Optional | \[{\rm{H[cm] = }}\left\{ {\begin{array}{*{20}{c}} {{\rm{177}},\;M}\\ {{\rm{163}},\;F} \end{array}} \right.\] | M = 163 cm, F = 151 cm | M = 190 cm, F = 175.5 cm | Min = 3rd percentile, Max = 97th percentile, Standard = 50th percentile. [108] |
| Body Fat Fraction | Optional | \[{\rm{Ff[cm] = }}\left\{ {\begin{array}{*{20}{c}} {{\rm{0}}{\rm{.21}},\;M}\\ {0.28,\;F} \end{array}} \right.\] | M = 0.25, F = 0.32 | M = 0.02, F = 0.10 | No obese and not less than essential fat. [231] |
| Carina To Teeth Distance | Optional | \[{\rm{Ctd[cm] = }}\left\{ {\begin{array}{*{20}{c}} {{\rm{11}}{\rm{.413 + (0}}{\rm{.072 H[cm]) - 3}},\;M}\\ {{\rm{13}}{\rm{.555 + (0}}{\rm{.056 H[cm]) - 3}},\;F} \end{array}} \right.\] | - | - | [121] |
| Blood Volume Baseline | Optional | \[Bv[mL] = 65.6W{[kg]^{1.02}}\] | Bv * 0.85 | Bv * 1.15 | Above Stage 1 Hypovolemia. [113] |
| Basal Metabolic Rate | Optional | \[{\rm{Bmr[kcal/day] = }}\left\{ {\begin{array}{*{20}{c}} {{\rm{88}}{\rm{.632 + 3}}{\rm{.397W[kg] + 4}}{\rm{.799H[cm] - 5}}{\rm{.677A[yr]}},\;M}\\ {{\rm{447}}{\rm{.593 + 9}}{\rm{.247W[kg] + 3}}{\rm{.098H[cm] - 4}}{\rm{.330A[yr]}},\;F} \end{array}} \right.\] | - | - | [300] |
| Heart Rate Baseline | Optional | \[Hr[bpm] = 72\] | 50 bpm | 110 bpm | Bradycardia < 60 bpm & Tachycardia > 100 bpm. |
| Systolic Arterial Pressure Baseline | Optional | \[Sys[mmHg] = 114\] | 90 mmHg | 120 mmHg | No hypotension or hypertension. |
| Diastolic Arterial Pressure Baseline | Optional | \[Dia[mmHg] = 73.5\] | 60 mmHg | 80 mmHg | No hypotension or hypertension. Includes pressure fraction check: Dia > 0.75 Sys. |
| Respiration Rate Baseline | Optional | \[Rr[bpm] = 16\] | 12 bpm | 20 bpm | |
| Alveoli Surface Area | Optional | \[Asa[{m^2}] = \frac{{{\rm{Tlc[L]}}}}{{6.17}} \times {\rm{70}}\] | - | - | Calculated using standard Tlc (6.17 L) [115] and standard Asa (70 m2) [284]. |
| Right Lung Ratio | Optional | \[Rlr = 0.525\] | 0.5 | 0.6 | |
| Skin Surface Area | Optional | \[Ssa[{m^2}] = 0.20247W{[kg]^{0.45}}H{[m]^{0.725}}\] | - | - | [78] |
| Heart Rate Maximum | Optional | \[H{r_{\max }}[bpm] = 208 - 0.7A[yr]\] | - | - | [344] |
| Heart Rate Minimum | Optional | \[H{r_{\min }}[bpm] = 0.001\] | - | - | |
| Functional Residual Capacity | Optional | \[Frc[mL] = 30W[kg]\] | - | - | [115] |
| Total Lung Capacity | Optional | \[Tlc[mL] = 80W[kg]\] | - | - | [115] |
| Residual Volume | Optional | \[Rv[mL] = 16W[kg]\] | - | - | [115] |
| Lean Body Mass | Unallowed | \[Lbm = W(1 - Ff)\] | - | - | |
| Body Density | Unallowed | \[Bd = {\left( {\frac{{4.95}}{{Ff + 4.5}} + \frac{{4.57}}{{Ff + 4.142}}} \right)}/2\] | - | - | Average of Siri [326] and Brozek [38] equations. |
| Mean Arterial Pressure | Unallowed | \[Map = \frac{1}{3}Sys + \frac{2}{3}Dia\] | - | - | [134] |
| Tidal Volume Baseline | Unallowed | \[Tv[mL] = 37W[kg] - Frc[mL]\] | - | - | [115] |
| Expiratory Reserve Volume | Unallowed | \[Erv = Frc - Rv\] | - | - | [115] |
| Inspiratory Capacity | Unallowed | \[Ic = Tlc - Frc\] | - | - | [115] |
| Inspriatory Reserve Volume | Unallowed | \[Irv = Ic - Tv\] | - | - | [115] |
| Vital Capacity | Unallowed | \[Vc - Tlc - Rv\] | - | - | [115] |
Stabilization
All patient parameters are set at the beginning of the resting stabilization period (see System Methodology). These values are used to modify the inner workings of systems. The complex interactions require a simulated period to allow physiological parameters to achieve homeostatic values. After each stabilization period (i.e., resting, conditions, and feedback), several parameters are reset due to their reliance on combined effects. The patient definition only allows for healthy values - any chronic pathophysiology needs to be handled using the CDM condition definition.
While every effort has been made to allow any combination of patient parameters within bounds, there is no guarantee that all combinations will be able to reach a stable starting homeostatic point.
Dependencies
Patient parameters are not dependent on any systems, but many systems are dependent on specific patient values. Some parameters are used to modify baseline fluid/thermal circuit values or direct calculation of outputs, and others manipulate how feedback mechanisms work. For details see the following system methodology sections regarding dependencies and patient variability:
Override Capabilities
Overview
Certain patient parameters can now have an override action called to change them mid-run. Currently BioGears operates utilizing a patient file to prepare a set of pre-defined patient-specific parameters which allow a user to modify a patient before a scenario run. If the user wants to modify a parameter during a scenario, then an override action must be used.
An override action consists of two required fields in addition to numerous optional parameter calls. The two required field are state and conformance. The state switch simply lets BioGears know whether the override action call is being turned on (to permit overrides) or off (to return to normal BioGears simulation). The conformance call determins whether the override is allowed to affect other BioGears parameters and conditions. Turning conformance off will only create a mask of the desired parameter in the simularion while turning it on will alter the scenario altogether. The conformance (on) feature is only currently compatible with certain parameters, though turning it on with an incompatible parameter will still allow an irreversible state (which is turned off when conformance is turned off). An example of a call would be as follows, with the override being turned on, set for an hour, and then turned off:
'''<Action xsi:type="OverrideData" State="On" Conformant="On"> <HeartRateOverride value="120" unit="1/min"> </Action> <Action xsi:type="AdvanceTimeData"> <Time value="1" unit="hr"> </Action> <Action xsi:type="OverrideData" State="Off" Conformant="On"> </Action>'''
The current list of override parameters (with conformance compatible parameters designated with a "Conf.") is as follows:
- Arterial Blood Pressure
- Calcium Concentration
- Carbon Dioxide Saturation
- Carbon Monoxide Saturation
- Glucose Concentration
- Lactate Concentration
- Oxygen Saturation
- Phosphate Concentration
- Potassium Concentration
- Sodium Concentration
- Total Bilirubin
- Venous Blood pH
- White Blood Cell Count
- Blood Volume
- Cardiac Output
- Diastolic Arterial Pressure - Conf.
- Heart Rate - Conf.
- Heart Stroke Volume
- Mean Arterial Pressure - Conf.
- Systolic Arterial Pressure - Conf.
- Insulin Synthesis Rate
- Glucagon Synthesis Rate
- Acheived Exercise Level
- Chloride Lost to Sweat
- Core Temperature
- Creatinine Production Rate
- Exercise Mean Arterial Pressure Delta
- Fatigue Level
- Lactate Production Rate
- Potassium Lost to Sweat
- Skin Temperature
- Sodium Lost to Sweat
- Sweat Rate
- Total Metabolic Rate
- Total Work Rate Level
- Left Afferent Arteriole Resistance
- Left Glomerular Filtration Rate
- Left Reabsorption Rate
- Renal Blood Flow
- Renal Plasma Flow
- Right Afferent Arteriole Resistance
- Right Glomerular Filtration Rate
- Right Reabsorption Rate
- Urination Rate
- Urine Osmolality
- Urine Volume
- Urine Urea Nitrogen Concentration
- Expiratory Flow
- Inspiratory Flow
- Pulmonary Compliance
- Pulmonary Resistance
- Respiration Rate - Conf.
- Target Pulmonary Ventilation
- Tidal Volume
- Total Alveolar Ventilation
- Total Lung Volume
- Total Pulmonary Ventilation
- Extravascular Fluid Volume
- Intracellular Fluid Volume
- Liver Glycogen
- Muscle Glycogen
- Stored Fat
- Stored Protein
Results and Conclusions
Verification and Validation
Table 2. There are several patients that we created for base validation, system-specific patient effects validation, and extreme case will stabilization.
| Name | Standard Male | Standard Female | Default Male | Default Female | Overweight | Underweight | Tachycardic | Bradycardic | Extreme Female | Extreme Male |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Male | Female | Male | Female | Male | Male | Male | Male | Female | Male |
| Age | 44 yr | 44 yr | - | - | 44 yr | 44 yr | 44 yr | 44 yr | 18 yr | 65 yr |
| Weight | 170 lb | 130 lb | - | - | 215 lb | 115 lb | 170 lb | 170 lb | - | - |
| Height | 71 in | 64 in | - | - | 71 in | 71 in | 71 in | 71 in | 4.5 ft | 7 ft |
| Body Fat Fraction | 0.21 | 0.28 | - | - | 0.25 | 0.15 | 0.18 | 0.18 | 0.32 | 0.02 |
| Heart Rate Baseline | 72 bpm | 72 bpm | - | - | 72 bpm | 72 bpm | 110 bpm | 50 bpm | 60 bpm | 100 bpm |
| Systolic Arterial Pressure Baseline | 114 mmHg | 114 mmHg | - | - | 114 mmHg | 114 mmHg | 114 mmHg | 114 mmHg | 90 mmHg | 120 mmHg |
| Diastolic Arterial Pressure Baseline | 73.5 mmHg | 73.5 mmHg | - | - | 73.5 mmHg | 73.5 mmHg | 73.5 mmHg | 73.5 mmHg | 60 mmHg | 80 mmHg |
| Respiration Rate Baseline | 16 bpm | 16 bpm | - | - | 16 bpm | 16 bpm | 20 bpm | 12 bpm | 12 bpm | 20 bpm |
| Right Lung Ratio | - | - | - | - | - | - | - | - | 0.5 | 0.6 |
Table 3. There are several patients we created for combined effects validation and showcase scenarios.
| Name | Cynthia | Gus | Joel | Nathan | Rick | Hassan | Soldier | Jeff | Carol | Jane |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Female | Male | Male | Male | Male | Male | Male | Male | Female | Female |
| Age | 30 yr | 32 yr | 44 yr | 44 yr | 23 yr | 28 yr | 22 yr | 25 yr | 40 yr | 18 yr |
| Weight | 130 lb | 190 lb | 170 lb | 170 lb | 161 lb | 185 lb | 170 lb | 180 lb | 160 lb | 120 lb |
| Height | 64 in | 70 in | 71 in | 71 in | 68 in | 72 in | 71 in | 72 in | 66 in | 64 in |
| Body Fat Fraction | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.12 | 0.25 | 0.18 |
| Heart Rate Baseline | 72 bpm | 93 bpm | 110 bpm | 72 bpm | 100 bpm | 110 bpm | 84 bpm | 72 bpm | 72 bpm | 72 bpm |
| Systolic Arterial Pressure Baseline | 114 mmHg | 90 mmHg | 120 mmHg | 114 mmHg | 120 mmHg | 90 mmHg | 114 mmHg | 114 mmHg | 114 mmHg | 114 mmHg |
| Diastolic Arterial Pressure Baseline | 73.5 mmHg | 60 mmHg | 80 mmHg | 73.5 mmHg | 80 mmHg | 60 mmHg | 73.5 mmHg | 73.5 mmHg | 73.5 mmHg | 73.5 mmHg |
| Respiration Rate Baseline | 18 bpm | 14 bpm | 15 bpm | 16 bpm | 16 bpm | 18 bpm | 16 bpm | 16 bpm | 18 bpm | 18 bpm |
All of the patients that are included with the BioGears deployment have been validated to ensure that they reach a homeostatic point that hits all of the defined criteria. The following tables show the state of the patients after all stabilization phases (see System Methodology for details) and compare the resulting patient values to those initially set/computed. Values that are explicitly set are expected to have very tight tolerances, while those that are initially calculated may drift due to the complex interaction of all patient parameters and system settings. The most sensitive of these parameters to external effects is tidal volume.
Values that are colored green are within 10% of the original set or calculated/estimated (expected) value, yellow are within 30%, and red are greater than 30% error. Values that are not within 10% are not necessarily a failure. As previously described, many of these are estimated before the stabilization simulation begins, and are really determined and overwritten after all other factors reach homeostasis. Those values that are explicitly set by the user/patient file should have much tighter tolerances.
| StandardMale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.209983 | -0.166572 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 61.294893 | 0.999037 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1736.855286 | 0.000283 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5533.538949 | -0.000187 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.353905 | -0.013094 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.782619 | -0.011074 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 114.589452 | -0.009128 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 515.957011 | -823.738455 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3055.745397 | -1036.378390 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1736.855286 | -38.473984 | |
| BloodVolume(mL) | 44.000000 | 5532.543230 | -124.739619 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.425802 | -0.691496 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.845883 | -1.178316 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| StandardFemale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 59.495043 | 0.233432 | |
| PatientHeight(in) | 71.000000 | 63.994668 | 0.098667 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 0.999917 | 0.054485 | |
| PatientBodyFatFraction | 0.180000 | 0.279977 | -0.555429 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 42.796434 | 0.999328 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 53.995501 | 0.228493 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.629864 | 0.171867 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1305.891194 | 0.248342 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 4221.648255 | 0.236937 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.290910 | -0.012236 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.094577 | -0.003812 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.339257 | 0.001882 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 422.964759 | -675.093733 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2233.813880 | -858.948543 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 2482.793135 | -694.218239 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 2058.828460 | -697.940479 | |
| PatientResidualVolume(mL) | 1.542214 | 1178.901775 | -763.421624 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 4716.607015 | -763.583715 | |
| PatientVitalCapacity(mL) | 4.626642 | 3537.705240 | -763.637745 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1305.891194 | -28.679345 | |
| BloodVolume(mL) | 44.000000 | 4221.018948 | -94.932249 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.180433 | -0.685919 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.043554 | -1.160081 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| DefaultMale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 68.594285 | 0.116192 | |
| PatientHeight(in) | 71.000000 | 69.994168 | 0.014167 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.209983 | -0.166572 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 54.195484 | 0.999148 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 61.994835 | 0.114195 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.839847 | 0.065175 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1600.866617 | 0.078557 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 4884.593018 | 0.117110 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.627082 | -0.016816 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.318658 | -0.006177 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 14.998750 | -0.199900 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.431249 | 0.001071 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 527.956011 | -842.918419 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2417.798550 | -929.776893 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3032.747313 | -848.213418 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 2505.791219 | -849.677436 | |
| PatientResidualVolume(mL) | 1.542214 | 1362.886445 | -882.720673 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 5450.545864 | -882.558582 | |
| PatientVitalCapacity(mL) | 4.626642 | 4087.659418 | -882.504551 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1600.866617 | -35.383332 | |
| BloodVolume(mL) | 44.000000 | 4883.716263 | -109.993551 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.635688 | -0.696266 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.401782 | -1.168222 | |
| RespirationRate(1/min) | 44.000000 | 14.548196 | 0.669359 |
| DefaultFemale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 58.295143 | 0.248892 | |
| PatientHeight(in) | 71.000000 | 63.994668 | 0.098667 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 0.999917 | 0.054485 | |
| PatientBodyFatFraction | 0.180000 | 0.279977 | -0.555429 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 41.996501 | 0.999340 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 51.995668 | 0.257067 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.619865 | 0.176947 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1295.892027 | 0.254098 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 4136.655336 | 0.252299 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 73.398484 | -0.000076 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 94.636915 | 0.001019 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 13.998834 | -0.119907 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.281761 | 0.002388 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 455.962009 | -727.838635 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2210.815796 | -850.095000 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 2411.799050 | -674.338861 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 1956.836957 | -663.315939 | |
| PatientResidualVolume(mL) | 1.542214 | 1155.903691 | -748.509243 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 4622.614846 | -748.347152 | |
| PatientVitalCapacity(mL) | 4.626642 | 3466.711156 | -748.293121 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1295.892027 | -28.452092 | |
| BloodVolume(mL) | 44.000000 | 4136.049178 | -93.001118 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 73.530272 | -0.671143 | |
| HeartRate(1/min) | 44.000000 | 72.007998 | -0.636545 | |
| MeanArterialPressure(mmHg) | 44.000000 | 94.778044 | -1.154046 | |
| RespirationRate(1/min) | 44.000000 | 14.258602 | 0.675941 |
| Overweight | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 97.991835 | -0.262583 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 0.999917 | 0.054485 | |
| PatientBodyFatFraction | 0.180000 | 0.249979 | -0.388776 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 73.493877 | 0.998845 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 88.992585 | -0.271558 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 2.169819 | -0.102484 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 2010.832459 | -0.157415 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 7017.415313 | -0.268398 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.621083 | -0.016735 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 96.108092 | -0.014510 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 115.048214 | -0.013168 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 606.949429 | -969.186516 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 3005.749563 | -1156.119660 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 4795.600433 | -1341.837967 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 4188.651004 | -1420.982354 | |
| PatientResidualVolume(mL) | 1.542214 | 1949.837541 | -1263.310574 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 7801.349996 | -1263.634756 | |
| PatientVitalCapacity(mL) | 4.626642 | 5850.512539 | -1263.526695 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 2010.832459 | -44.700738 | |
| BloodVolume(mL) | 44.000000 | 7015.295991 | -158.438545 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.696793 | -0.697654 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 96.192721 | -1.186198 | |
| RespirationRate(1/min) | 44.000000 | 15.238024 | 0.653681 |
| Underweight | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 52.695609 | 0.321040 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.149988 | 0.166735 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 44.796268 | 0.999296 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 46.996084 | 0.328503 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.669861 | 0.151544 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1402.883113 | 0.192515 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 3731.689078 | 0.325497 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 73.640064 | -0.003368 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.045181 | -0.003290 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.885611 | -0.002930 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 463.961343 | -740.625277 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2098.825127 | -806.982092 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 2073.827210 | -579.701823 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 1610.865784 | -545.864066 | |
| PatientResidualVolume(mL) | 1.542214 | 1042.913105 | -675.244066 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 4172.652337 | -675.406157 | |
| PatientVitalCapacity(mL) | 4.626642 | 3129.739232 | -675.460187 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1402.883113 | -30.883707 | |
| BloodVolume(mL) | 44.000000 | 3734.655629 | -83.878537 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 73.365483 | -0.667397 | |
| HeartRate(1/min) | 44.000000 | 72.106473 | -0.638783 | |
| MeanArterialPressure(mmHg) | 44.000000 | 94.850428 | -1.155692 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| Tachycardic | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 63.594701 | 0.999001 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1736.855286 | 0.000283 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5533.538949 | -0.000187 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.358305 | -0.013154 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 108.990919 | -1.179818 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.600335 | -0.009150 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 18.998417 | -0.519873 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 114.637848 | -0.009554 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 438.963426 | -700.667019 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3131.739065 | -1062.177067 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1736.855286 | -38.473984 | |
| BloodVolume(mL) | 44.000000 | 5533.584726 | -124.763289 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.393084 | -0.690752 | |
| HeartRate(1/min) | 44.000000 | 108.990919 | -1.477066 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.607313 | -1.172893 | |
| RespirationRate(1/min) | 44.000000 | 18.998417 | 0.568218 |
| Bradycardic | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 63.594701 | 0.999001 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1736.855286 | 0.000283 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5532.539032 | -0.000007 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 73.373887 | 0.000259 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 49.995834 | 0.000083 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 94.715008 | 0.000195 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 12.998917 | -0.039913 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.534340 | 0.000164 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 629.947513 | -1005.948114 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 2941.754895 | -997.680374 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1736.855286 | -38.473984 | |
| BloodVolume(mL) | 44.000000 | 5529.827190 | -124.677891 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 73.284670 | -0.665561 | |
| HeartRate(1/min) | 44.000000 | 49.995834 | -0.136269 | |
| MeanArterialPressure(mmHg) | 44.000000 | 94.678411 | -1.151782 | |
| RespirationRate(1/min) | 44.000000 | 12.333750 | 0.719688 |
| Cynthia | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 29.997501 | 0.318239 | |
| PatientWeight(kg) | 77.612203 | 59.495043 | 0.233432 | |
| PatientHeight(in) | 71.000000 | 63.994668 | 0.098667 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 48.795934 | 0.999233 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 53.995501 | 0.228493 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.629864 | 0.171867 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1366.886112 | 0.213234 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 4221.648255 | 0.236937 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.320708 | -0.012642 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.129074 | -0.004176 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 17.998500 | -0.439880 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.380753 | 0.001516 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 388.967591 | -620.750502 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 186.984421 | -0.055217 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2234.813797 | -859.333480 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 2482.793135 | -694.218239 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 2093.825544 | -709.821449 | |
| PatientResidualVolume(mL) | 1.542214 | 1178.901775 | -763.421624 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 4716.607015 | -763.583715 | |
| PatientVitalCapacity(mL) | 4.626642 | 3537.705240 | -763.637745 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1366.886112 | -30.065593 | |
| BloodVolume(mL) | 44.000000 | 4221.275368 | -94.938077 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.398525 | -0.690876 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.250491 | -1.164784 | |
| RespirationRate(1/min) | 44.000000 | 17.998500 | 0.590943 |
| Gus | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 31.997334 | 0.272788 | |
| PatientWeight(kg) | 77.612203 | 86.692777 | -0.116999 | |
| PatientHeight(in) | 71.000000 | 69.994168 | 0.014167 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 71.094076 | 0.998883 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 77.993502 | -0.114399 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 2.039830 | -0.036437 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1914.840457 | -0.102163 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 6194.483879 | -0.119653 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 59.799718 | 0.185211 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 92.992252 | -0.859845 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 75.892777 | 0.198881 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 13.998834 | -0.119907 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 90.015500 | 0.207281 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 626.947763 | -1001.153123 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 185.984504 | -0.049574 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2778.768475 | -1068.739034 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 4114.657169 | -1151.163936 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3487.709406 | -1183.023503 | |
| PatientResidualVolume(mL) | 1.542214 | 1723.856369 | -1116.780220 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6894.425560 | -1116.618129 | |
| PatientVitalCapacity(mL) | 4.626642 | 5170.569191 | -1116.564099 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1914.840457 | -42.519101 | |
| BloodVolume(mL) | 44.000000 | 6197.856957 | -139.860385 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 59.763105 | -0.358252 | |
| HeartRate(1/min) | 44.000000 | 92.992252 | -1.113460 | |
| MeanArterialPressure(mmHg) | 44.000000 | 75.882561 | -0.724604 | |
| RespirationRate(1/min) | 44.000000 | 13.998834 | 0.681845 |
| Joel | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 63.594701 | 0.999001 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1736.855286 | 0.000283 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5532.539032 | -0.000007 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 80.776170 | -0.100600 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 108.990919 | -1.179818 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 102.165388 | -0.078451 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 14.998750 | -0.199900 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 121.107109 | -0.066526 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 537.955178 | -858.901722 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3032.747313 | -1028.570895 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1736.855286 | -38.473984 | |
| BloodVolume(mL) | 44.000000 | 5530.170550 | -124.685694 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 80.678154 | -0.833594 | |
| HeartRate(1/min) | 44.000000 | 109.211364 | -1.482076 | |
| MeanArterialPressure(mmHg) | 44.000000 | 102.147058 | -1.321524 | |
| RespirationRate(1/min) | 44.000000 | 14.998750 | 0.659119 |
| Nathan | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 43.996334 | 0.000083 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 63.594701 | 0.999001 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1736.855286 | 0.000283 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5533.538949 | -0.000187 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.386302 | -0.013536 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.818016 | -0.011448 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 114.623250 | -0.009426 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 514.957094 | -822.140125 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 176.985254 | 0.001212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3055.745397 | -1036.378390 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1736.855286 | -38.473984 | |
| BloodVolume(mL) | 44.000000 | 5532.617002 | -124.741295 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.470322 | -0.692507 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.892947 | -1.179385 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| Hassan | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 27.997667 | 0.363689 | |
| PatientWeight(kg) | 77.612203 | 84.392968 | -0.087367 | |
| PatientHeight(in) | 71.000000 | 71.994001 | -0.014000 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 69.194235 | 0.998913 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 75.993668 | -0.085825 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 2.059828 | -0.046598 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1931.839040 | -0.111947 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 6030.497542 | -0.090013 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 60.088793 | 0.181272 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 108.990919 | -1.179818 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 75.724691 | 0.200656 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 17.998500 | -0.439880 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 90.082294 | 0.206693 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 522.956428 | -834.926767 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 187.984337 | -0.060860 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2733.772224 | -1051.416883 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3978.668500 | -1113.085128 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3455.712072 | -1172.160902 | |
| PatientResidualVolume(mL) | 1.542214 | 1677.860202 | -1086.955458 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6712.440723 | -1087.117549 | |
| PatientVitalCapacity(mL) | 4.626642 | 5034.580522 | -1087.171579 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1931.839040 | -42.905433 | |
| BloodVolume(mL) | 44.000000 | 6034.227818 | -136.141541 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 60.108785 | -0.366109 | |
| HeartRate(1/min) | 44.000000 | 108.990919 | -1.477066 | |
| MeanArterialPressure(mmHg) | 44.000000 | 75.758463 | -0.721783 | |
| RespirationRate(1/min) | 44.000000 | 17.998500 | 0.590943 |
| Soldier | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 21.998167 | 0.500042 | |
| PatientWeight(kg) | 77.612203 | 77.593535 | 0.000241 | |
| PatientHeight(in) | 71.000000 | 70.994085 | 0.000083 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 63.594701 | 0.999001 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 69.994168 | -0.000102 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.969836 | -0.000873 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1861.844872 | -0.071659 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5532.539032 | -0.000007 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.389902 | -0.013585 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 83.993002 | -0.679860 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.436448 | -0.007420 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 114.429966 | -0.007724 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 531.955678 | -849.311740 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 192.983921 | -0.089074 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2597.783554 | -999.065495 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3570.702491 | -998.848703 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3039.746730 | -1030.947089 | |
| PatientResidualVolume(mL) | 1.542214 | 1541.871532 | -998.777900 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6168.486045 | -998.939991 | |
| PatientVitalCapacity(mL) | 4.626642 | 4626.614513 | -998.994021 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1861.844872 | -41.314656 | |
| BloodVolume(mL) | 44.000000 | 5532.539718 | -124.739539 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.412576 | -0.691195 | |
| HeartRate(1/min) | 44.000000 | 83.993002 | -0.908932 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.517445 | -1.170851 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| Jeff | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 24.997917 | 0.431866 | |
| PatientWeight(kg) | 77.612203 | 82.093160 | -0.057735 | |
| PatientHeight(in) | 71.000000 | 71.994001 | -0.014000 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.119990 | 0.333388 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 72.293977 | 0.998864 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 73.993835 | -0.057251 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 2.039830 | -0.036437 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1917.840207 | -0.103890 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5862.511539 | -0.059649 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 74.229515 | -0.011400 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.767721 | -0.010917 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 15.998667 | -0.279893 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 114.733240 | -0.010395 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 540.954928 | -863.696713 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 190.984087 | -0.077788 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2687.776056 | -1033.709796 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3842.679830 | -1075.006319 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 3301.724902 | -1119.884635 | |
| PatientResidualVolume(mL) | 1.542214 | 1632.863951 | -1057.779060 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 6531.455803 | -1057.779060 | |
| PatientVitalCapacity(mL) | 4.626642 | 4898.591852 | -1057.779060 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1917.840207 | -42.587277 | |
| BloodVolume(mL) | 44.000000 | 5861.689782 | -132.220222 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 74.284464 | -0.688283 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 95.818407 | -1.177691 | |
| RespirationRate(1/min) | 44.000000 | 15.998667 | 0.636394 |
| Carol | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 39.996667 | 0.090985 | |
| PatientWeight(kg) | 77.612203 | 73.093910 | 0.058216 | |
| PatientHeight(in) | 71.000000 | 65.994501 | 0.070500 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 0.999917 | 0.054485 | |
| PatientBodyFatFraction | 0.180000 | 0.249979 | -0.388776 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 54.795434 | 0.999139 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 65.994501 | 0.057047 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.819848 | 0.075336 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1464.877947 | 0.156831 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 5205.566275 | 0.059094 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 73.766054 | -0.005085 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 94.887894 | -0.001630 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 17.998500 | -0.439880 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.482745 | 0.000618 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 434.963759 | -694.273697 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 179.985004 | -0.015717 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2506.791136 | -964.036257 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 3298.725152 | -922.691087 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 2863.761393 | -971.202784 | |
| PatientResidualVolume(mL) | 1.542214 | 1450.879114 | -939.776740 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 5805.516288 | -940.100922 | |
| PatientVitalCapacity(mL) | 4.626642 | 4353.637257 | -939.992861 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1464.877947 | -32.292681 | |
| BloodVolume(mL) | 44.000000 | 5204.161419 | -117.276396 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 73.828125 | -0.677912 | |
| HeartRate(1/min) | 44.000000 | 71.994001 | -0.636227 | |
| MeanArterialPressure(mmHg) | 44.000000 | 94.949391 | -1.157941 | |
| RespirationRate(1/min) | 44.000000 | 16.998584 | 0.613669 |
| Jane | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 17.998500 | 0.590943 | |
| PatientWeight(kg) | 77.612203 | 54.895426 | 0.292696 | |
| PatientHeight(in) | 71.000000 | 63.994668 | 0.098667 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.179985 | 0.000081 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 44.996251 | 0.999293 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 48.995918 | 0.299929 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.569869 | 0.202350 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1376.885279 | 0.207479 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 3894.675498 | 0.296037 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 73.565871 | -0.002357 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 71.994001 | -0.439880 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 95.032482 | -0.003156 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 18.998417 | -0.519873 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 113.914409 | -0.003184 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 402.966425 | -643.127127 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 194.983754 | -0.100360 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 2143.821378 | -824.304242 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 2210.815796 | -618.060622 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 1806.849454 | -612.397497 | |
| PatientResidualVolume(mL) | 1.542214 | 1088.909273 | -705.068828 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 4353.637257 | -704.744646 | |
| PatientVitalCapacity(mL) | 4.626642 | 3265.727901 | -704.852707 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1376.885279 | -30.292847 | |
| BloodVolume(mL) | 44.000000 | 3895.121079 | -87.525479 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 73.403952 | -0.668272 | |
| HeartRate(1/min) | 44.000000 | 72.056986 | -0.637659 | |
| MeanArterialPressure(mmHg) | 44.000000 | 94.950665 | -1.157970 | |
| RespirationRate(1/min) | 44.000000 | 18.998417 | 0.568218 |
| ExtremeFemale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 17.998500 | 0.590943 | |
| PatientWeight(kg) | 77.612203 | 41.396551 | 0.466623 | |
| PatientHeight(in) | 71.000000 | 53.995501 | 0.239500 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 0.999917 | 0.054485 | |
| PatientBodyFatFraction | 0.180000 | 0.319973 | -0.777633 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 28.197651 | 0.999557 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 36.996917 | 0.471375 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 1.229898 | 0.375090 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 1172.902274 | 0.324889 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 2925.756228 | 0.471170 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 57.817583 | 0.212218 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 59.995001 | -0.199900 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 74.332307 | 0.215353 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 11.999000 | 0.040080 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 88.865196 | 0.217412 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 460.961593 | -735.830286 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 194.983754 | -0.100360 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1054.912105 | -998.538317 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 1872.843956 | -719.986402 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 1399.883362 | -390.987730 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 938.921770 | -317.749446 | |
| PatientResidualVolume(mL) | 1.542214 | 817.931850 | -529.362077 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 3272.727318 | -529.524168 | |
| PatientVitalCapacity(mL) | 4.626642 | 2454.795468 | -529.578198 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 1172.902274 | -25.656870 | |
| BloodVolume(mL) | 44.000000 | 2931.295679 | -65.620356 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 57.634636 | -0.309878 | |
| HeartRate(1/min) | 44.000000 | 60.457386 | -0.374031 | |
| MeanArterialPressure(mmHg) | 44.000000 | 74.267485 | -0.687897 | |
| RespirationRate(1/min) | 44.000000 | 12.828959 | 0.708433 |
| ExtremeMale | Expected Value | Engine Value | Percent Error | Notes |
|---|---|---|---|---|
| PatientAge(yr) | 44.000000 | 64.994585 | -0.477150 | |
| PatientWeight(kg) | 77.612203 | 99.491710 | -0.281908 | |
| PatientHeight(in) | 71.000000 | 83.993002 | -0.183000 | |
| PatientBodyDensity(g/cm^3) | 1.057537 | 1.099908 | -0.040066 | |
| PatientBodyFatFraction | 0.180000 | 0.019998 | 0.888898 | |
| PatientLeanBodyMass(kg) | 63642.033057 | 97.491877 | 0.998468 | |
| PatientAlveoliSurfaceArea(m^2) | 69.987024 | 89.992502 | -0.285846 | |
| PatientRightLungRatio | 0.525000 | 0.529956 | -0.009440 | |
| PatientSkinSurfaceArea(m^2) | 1.968118 | 2.469794 | -0.254901 | |
| PatientBasalMetabolicRate(kcal/day) | 1737.347747 | 2069.827543 | -0.191372 | |
| PatientBloodVolumeBaseline(mL) | 5532.502834 | 7124.406398 | -0.287737 | |
| PatientDiastolicArterialPressureBaseline(mmHg) | 73.392872 | 80.809167 | -0.101049 | |
| PatientHeartRateBaseline(1/min) | 50.000000 | 99.991669 | -0.999833 | |
| PatientMeanArterialPressureBaseline(mmHg) | 94.733494 | 101.985603 | -0.076553 | |
| PatientRespirationRateBaseline(1/min) | 12.500000 | 18.998417 | -0.519873 | |
| PatientSystolicArterialPressureBaseline(mmHg) | 113.552910 | 120.806834 | -0.063881 | |
| PatientTidalVolumeBaseline(mL) | 0.625601 | 545.954511 | -871.688365 | |
| PatientHeartRateMaximum(1/min) | 177.200000 | 162.986420 | 0.080212 | |
| PatientHeartRateMinimum(1/min) | 0.001000 | 0.001000 | 0.000083 | |
| PatientExpiratoryReserveVolume(mL) | 1.055399 | 1055.912022 | -999.485746 | |
| PatientFunctionalResidualCapacity(mL) | 2.597613 | 3035.747063 | -1167.667761 | |
| PatientInspiratoryCapacity(mL) | 3.571243 | 4884.593018 | -1366.757187 | |
| PatientInspiratoryReserveVolume(mL) | 2.945642 | 4338.638507 | -1471.900796 | |
| PatientResidualVolume(mL) | 1.542214 | 1979.835041 | -1282.761506 | |
| PatientTotalLungCapacity(mL) | 6.168856 | 7920.340082 | -1282.923597 | |
| PatientVitalCapacity(mL) | 4.626642 | 5940.505040 | -1282.977627 | |
| TotalMetabolicRate(kcal/day) | 44.000000 | 2069.827543 | -46.041535 | |
| BloodVolume(mL) | 44.000000 | 7122.416318 | -160.873098 | |
| DiastolicArterialPressure(mmHg) | 44.000000 | 80.755202 | -0.835346 | |
| HeartRate(1/min) | 44.000000 | 99.991669 | -1.272538 | |
| MeanArterialPressure(mmHg) | 44.000000 | 101.971579 | -1.317536 | |
| RespirationRate(1/min) | 44.000000 | 18.998417 | 0.568218 |
Conclusions
The methodology used to define and set patient parameters is successful in allowing for the simulation of unique humans.
Future Work
Coming Soon
There are no planned near-term additions.
Recommended Improvements
The BioGears physiology engine is providing consistent and accurate physiology simulation, and its ability to simulate physiology for a generic representative of a population will improve as development continues. It is not within the scope of the current project for BioGears to predictively simulate the physiology of a specific (or average) individual within a population, but the development of technologies that make BioGears usable and extensible to the community also facilitate multiscale model development and can be leveraged for predictive simulation and thus clinical use.
One way to extend BioGears for clinical use is to use data from sources such as electronic health records (EHRs), lab reports, fitness evaluations, or wearable sensors to create a personalized physiological profile. A tool could then translate the personal physiological profile into parameters that can inform the BioGears physiology models within the systems' framework.
Appendices
Acronyms
CDM - Common Data Model
Data Model Implementation
BioGears
